منابع مشابه
Taurine and vascular tone modulation
Taurine, an ubiquitary amino acid in the organism, has important physiological functions like bile salt formation, neuronal excitability regulation, immunomodulation, electrolytes homeostasis preservation, osmoregulation, membrane stabilisation, apoptosis inhibition and cell protection. This review article is focusing on the complex vasoactive influence of the sulphur-amino acid and on the poss...
متن کاملRedox modulation of vascular tone: focus of potassium channel mechanisms of dilation.
Opening of potassium channels on vascular smooth muscle cells with resultant hyperpolarization plays a central role in several mechanisms of vasodilation. For example, in the arteriolar circulation where tissue perfusion is regulated, there is an endothelial derived hyperpolarizing factor that opens vascular smooth muscle calcium-activated potassium channels, eliciting dilation. Metabolic vasod...
متن کاملEndothelial modulation of pulmonary vascular tone.
Pulmonary endothelial cells normally synthesize prostacyclin (PGI2) and nitric oxide (NO), which are both potent vasodilators. Although PGI2 is largely used to treat patients with severe pulmonary hypertension, its role in the physiology and pathophysiology of the pulmonary circulation is still debated. NO, which is now considered as the endogenous nitrovasodilator, is perhaps more involved tha...
متن کاملImplications of prostacyclin generation for modulation of vascular tone.
1. The biotransformation of arachidonic acid and prostacyclin in the circulation was studied in anaesthetized dogs, using the blood-bathed organ technique. 2. In passage through the lungs, arachidonate (50-800 microgram kg-1 min-1) was transformed into prostacyclin. No thromboxane A2 or prostaglandin E2 could be detected in arterial blood. 3. In dogs treated with indomethacin (5 mg/kg), intrave...
متن کاملRegulation of coronary vascular tone via redox modulation in the 1-adrenergic-angiotensin-endothelin axis of the myocardium
Yamaguchi O, Kaneshiro T, Saitoh S, Ishibashi T, Maruyama Y, Takeishi Y. Regulation of coronary vascular tone via redox modulation in the 1-adrenergic-angiotensin-endothelin axis of the myocardium. Am J Physiol Heart Circ Physiol 296: H226–H232, 2009. First published November 21, 2008; doi:10.1152/ajpheart.00480.2008.—We hypothesized that 1-adrenoceptor stimulation of cardiac myocytes results i...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2005
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.0000158497.09626.3b